B-ESTRADIOL (C005B-044988)

Application

β-Estradiol has been used:

• for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
• as a supplement in in vitro maturation medium (IVM), which is used as a control medium
• in estrogen-induction assay

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Nuclear Receptors (Steroids) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Molecular Weight: 272.38. Empirical Formula: C₁₈H₂₄O₂. biological source: synthetic (organic). Quality Level: 200. sterility: non-sterile. Assay: ≥. 98%. form: powder. technique(s): cell culture | mammalian: suitable. mp: 176-180 . °C (lit.). solubility: ethanol: 50 . mg/mL, clear, colorless. shipped in: ambient. storage temp.: room temp. SMILES string: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4: CC(O): CC: C4[C@@]3([H])CC[C@@]21C. InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1. InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N. Gene Information: human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775). Pictograms: GHS08,GHS09. Signal Word: Danger. Hazard Statements: H351 - H360FD - H362 - H410. Precautionary Statements: P202 - P260 - P263 - P264 - P273 - P308 + P313. Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges.