AURINTRICARBOXYLIC ACID PRACTICAL GRADE (C005B-040357)

Application

• Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
• It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
• It has been used as a ribonuclease inhibitor.

Biochem/physiol Actions

Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.

Molecular Weight: 422.34. Empirical Formula: C₂₂H₁₄O₉. grade: practical grade. Quality Level: 300. Assay: ≥. 85% (titration). form: powder. color: dark red to brown. mp: 300 . °C (lit.). solubility: 1 M NH4OH: 10 . mg/mL. application(s): diagnostic assay manufacturing
hematology
histology. storage temp.: room temp. SMILES string: OC(: O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O): O): C3\C: CC(: O)C(: C3)C(O): O. InChI: 1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31). InChI key: GIXWDMTZECRIJT-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.