AURINTRICARBOXYLIC ACID TRIAMMONIUM (C005B-049436)

Application

Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.

Biochem/physiol Actions

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.

Other Notes

May contain a substantial amount of polymeric material.

Molecular Weight: 473.43. Empirical Formula: C₂₂H₂₃N₃O₉. linearFormula: C₂₂H₁₄O₉ · 3NH₃. biological source: synthetic. Quality Level: 200. form: powder. mp: 220-225 . °C (dec.) (lit.). solubility: water: soluble 100 . mg/mL, dark red. λ. _max: 552 nm (λ. max: ). application(s): diagnostic assay manufacturing
hematology
histology. storage temp.: room temp. SMILES string: N.N.N.OC(: O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O): O): C3/C: CC(: O)C(: C3)C(O): O. InChI: 1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31. . . /h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31). 3*1H3. InChI key: AIPNSHNRCQOTRI-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.