ALSTERPAULLONE

Application

Alsterpaullone has been used to stabilize β-catenin.

Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.

Biochem/physiol Actions

Alsterpaullone (ALP) is a cyclin-dependent kinase (CDK) inhibitor. It is considered as a therapeutic agent for group 3 medulloblastomas. Alsterpaullone modulates the progression of cell cycle. It can arrest cell cycle and stimulate the apoptosis of cancer cells by activating caspase-9 through perturbation of mitochondrial membrane potential.

Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC₅₀ = 0.035 μM).

Features and Benefits

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Molecular Weight: 293.28. Empirical Formula: C₁₆H₁₁N₃O₃. Quality Level: 100. Assay: ≥. 98% (HPLC). form: powder. storage condition: desiccated. color: yellow to brown. solubility: DMSO: ≥. 10 . mg/mL. storage temp.: 2-8°C. SMILES string: [O-][N+](: O)c1ccc2[nH]c-3c(CC(: O)Nc4ccccc-34)c2c1. InChI: 1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20). InChI key: OLUKILHGKRVDCT-UHFFFAOYSA-N. Gene Information: rat ... Gsk3b(84027). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.