Alsterpaullone, 2-Cyanoethyl

Catalog No.: C007B-018812
Manufacturer No.: A336672-1mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

Alsterpaullone, 2-Cyanoethyl is an alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 μM). Alsterpaullone, 2-Cyanoethyl displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). In a commercially available testing screen panel, Alsterpaullone, 2-Cyanoethyl was shown to inhibit other kinases (pIC50 = -logIC50[M]; pIC50 ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 μM).

Specifications and Purity: ≥97%

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/A336672-SCI_b762747dbbebc51221bc2e03ccde0631.pdf

UPC:: 51111613
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: A336672-1mg
Product Size:: 1mg
Precautionary Statement Codes:: P264

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