17A-ESTRADIOL (C005B-049988)

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

Molecular Weight: 272.38. Empirical Formula: C₁₈H₂₄O₂. biological source: synthetic (organic). Quality Level: 200. Assay: ≥. 98% (TLC). form: powder. color: white to slight yellow. solubility: ethanol: 50 . mg/mL, clear, colorless. shipped in: ambient. storage temp.: room temp. SMILES string: [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24. InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1. InChI key: VOXZDWNPVJITMN-SFFUCWETSA-N. Gene Information: human ... ESR1(2099), ESR2(2100)
rat ... Ar(24208). Pictograms: GHS08,GHS09. Signal Word: Danger. Hazard Statements: H341 - H351 - H360F - H362 - H410. Precautionary Statements: P202 - P260 - P263 - P264 - P273 - P308 + P313. Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.