AKT INHIBITOR - CALBIOCHEM

General description

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1 - 10 µM range.

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1-10 µM range.

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 5.0 µM for Akt (PKB)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.

Use anhydrous DMSO for reconstitution.

Other Notes

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 578.78. Empirical Formula: C₃₀H₅₈O₁₀. Quality Level: 100. Assay: ≥. 98% (NMR). form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, desiccated (hygroscopic). color: white to off-white. solubility: DMSO: 200 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.