2'-DEOXYINOSINE (C005B-086397)

Application

2′-Deoxyinosine has been used in the quantification of nucleoside forms of DNA lesion in a single DNA sample by liquid chromatography tandem mass spectrometry (LC-MS/MS). It has also been used as a standard for high performance liquid chromatography analysis.

Biochem/physiol Actions

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. 2′-Deoxyinosine in DNA can arise from deamination of adenosine. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

2′-Deoxyinosine is a nucleoside form of hypoxanthine. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinosine is formed from nitrosative deamination by N₂O₃.

Molecular Weight: 252.23. Empirical Formula: C₁₀H₁₂N₄O₄. biological source: synthetic (organic). Quality Level: 200. Assay: ≥. 98%. form: powder. impurities: inosine, essentially free. solubility: 1 M NH₄OH: 50 . mg/mL, clear, colorless. storage temp.: −. 20°C. SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(: O)NC: Nc23. InChI: 1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1. InChI key: VGONTNSXDCQUGY-RRKCRQDMSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).