Zafirlukast

Zafirlukast is a leukotriene receptor antagonist (LTRA). (IC50=0.6μM, IC50=7.0 μM for CYP2C9).A potent and selective CysLT1 receptor antagonist.Product description： Zafirlukast is a potent leukotriene D4 (LTD4) receptor antagonist with oral activity. Zafirlukast has antiasthmatic, anti-inflammatory and antibacterial effects Zafirlukast has been used to stimulate pancreatic β cell line (MIN6) and pancreatic islets for insulin secretion assay. It may be used as an adenosine triphosphate-binding cassette transporter (ABCG2) inhibitor in MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cytotoxicity assay in human embryonic kidney cells (HEK293) and in Kirby-Bauer disc diffusion assays, bactericidal activity and minimal inhibitory concentration (mIC) assay against M. smegmatis

Specification: Moligand™, ≥99%

MDL Number: MFCD00864775

Molecular Formula: C31H33N3O6S

Molecular Weight: 575.68

PubChem CID: 5717

Isomeric SMILES: CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(C=C2)CC3=CN(C4=C3C=C(C=C4)NC(=O)OC5CCCC5)C)OC

Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Z129979-SCI_602cd6521a50de7b7c9fa9c500f205a7.pdf