YUMM1.7D5 MOUSE MELANOMA CELL LINE (C005B-315627)

Application

• Each vial contains > 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR Panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, human, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.

The great promise of immune-based therapies in cancer and recent progress in successful application of these approaches has brought to the fore the necessity of immune-competent models to evaluate immune system responses to cancer cells. Melanomas exhibit relatively high somatic mutation burden, and these mutations may act as neoantigens that generate anti-tumor immune responses. The development of immunocompetent cell models is critical to the advancement of cancer immunotherapy and understanding of immunity, although few tractable model systems are available.


References
1. Pigment Cell Melanoma Res 2016, 29(5): 590-597.
2. Nat Genet 2009, 41(5): 544-552.
3. Pigment Cell Melanoma Res 2017, 30(4): 428-435.
4. Ramseier JY, Charos A, Park K, Damsky W, Bosenberg MW (2019). Cancer Res 79(13 Suppl) Abstract #4622.

Features and Benefits

The characteristics of the YUMMER1.G1F cell line make it a valuable model for investigating sex-related differences in immune checkpoint inhibition and mechanisms of anti-tumor responses.

Storage and Stability

The cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.;<bold>This product contains genetically modified organisms (GMO). </bold>Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges to request certain information about you and the establishment where the GMOs are being handled. <IS7_ContentPageCategoryLink target="Up.b.qB.CN8AAAFAnd8QWRbW">Click here for Enduser Declaration (EUD) Form</IS7_ContentPageCategoryLink>.