YM-58483 >=98% (HPLC) (C005B-273212)

Catalog No.: C005B-273212
Manufacturer No.: Y4895-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Application YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells. Biochem/physiol Actions YM-58483 is a selective Ca ++ release-activated Ca ++ (CRAC) [a.

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Description
Specifications

Application

YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells.

Biochem/physiol Actions

YM-58483 is a selective Ca⁺⁺ release-activated Ca⁺⁺ (CRAC) [a.k.a. store-operated Ca⁺⁺ (SOC) channels] that mediate Ca⁺⁺ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:: 41106223
Condition:: New
HazmatClass:: No
MPN:: Y4895-25MG
CAS:: 223499-30-7

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