XPHOS PD G2 CHEMBEADS

General description

XPhos Pd G2 is a bulky monodentate biaryl ligand. It is a Buchwald′s 2nd generation preformed catalyst. It undergoes rapid reductive elimination to form a reactive, monoligated Pd(0) species.

For larger scale uses, product also available in powdered form (741825)

Application

XPhos Pd G2 was employed as catalyst in the following reactions:

• Palladium-catalyzed Suzuki-Miyaura coupling reactions of potassium organotrifluoroborates and sulfamates.
• Suzuki-Miyaura cross-coupling reactions of sensitive aryl and heteroarylboronic acids.
• Synthesis of potassium Boc-protected secondary aminomethyltrifluoroborates, via Suzuki-Miyaura cross-coupling reaction.

2nd Generation Buchwald Precatalysts

• Widely used for Suzuki-Miyaura cross-coupling reactions
• ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
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Other Notes

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

Molecular Weight: 786.80. Empirical Formula: C₄₅H₅₉ClNPPd. form: solid. Quality Level: 100. composition: ~ 5 wt.% loading of catalyst . reaction suitability: reagent type: catalyst
reaction type: Cross Couplings. SMILES string: Cl[Pd@@]1(C2: C(C3: C(N1)C: CC: C3)C: CC: C2)P(C4CCCCC4)(C5: CC: CC: C5C6: C(C(C)C)C: C(C(C)C)C: C6C(C)C)C7CCCCC7. InChI: 1S/C33H49P.C12H10N.ClH.Pd/c1-23(2)26-21-30(24(3)4)33(31(22-26)25(5)6)29-19-13-14-20-32(29)34(27-15-9-7-10-16-27)28-17-11-8-12-18-28. 13-12-9-5-4-8-11(12)10-6-2-1-3-7-10. . /h13-14,19-25,27-28H,7-12,15-18H2,1-6H3. 1-6,8-9H,13H2. 1H. /q. -1. . +2/p-1. InChI key: HLXMDSGYOJBEBA-UHFFFAOYSA-M. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3.