XIE62-1004 (C005B-310356)

Catalog No.: C005B-310356
Manufacturer No.: SML2638-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and

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Description
Specifications

Biochem/physiol Actions

XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 μM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 μM, 18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectants, as well as in wild-type, but not autophagy defective Atg5-/- MEFs (GFP-HDQ103).

UPC:: 10161817
Condition:: New
HazmatClass:: No
MPN:: SML2638-5MG
CAS:: 500899-98-9

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