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ws6

WS6 (C007B-308794)

Catalog No.
C007B-308794
Manufacturer No.
W413752-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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InformationWS6 is a β cell proliferation inducer via modulation ofErb3 binding protein-1 (EBP1)and theIκB kinasepathway.TargetsEBP1 : IκB kinaseIn vitroWS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in

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InformationWS6 is a β cell proliferation inducer via modulation ofErb3 binding protein-1 (EBP1)and theIκB kinasepathway.TargetsEBP1 ; IκB kinaseIn vitroWS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6.In vivoIn RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number.Cell Research(from reference)Cell lines：R7T1 cells Concentrations：~10 μM Incubation Time：4 days.

Specifications and Purity: ≥98%

Molecular Formula: C29H31F3N6O3

Molecular Weight: 568.59

PubChem CID: 71566751

Isomeric SMILES: CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/W413752-SCI_4dba66da3222a0269784f68d15c1274a.pdf

UPC:
41115304
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
W413752-5mg
CAS:
1421227-53-3
Product Size:
5mg
Hazard Statement Codes:
H335:H319:H315:H302
Precautionary Statement Codes:
P305+P351+P338:P261

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