WEHI-9625 (C007B-433113)

WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAXIn VitroWEHI-9625 (0-10 µM; Mcl1 −/− Bax −/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax −/− , but not Bak −/− , cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mcl1 −/− Bax −/− MEFs cells with ABT-737-pretreated Concentration: 0-10 µM Incubation Time: Result: Could prevent cell death.In VivoWEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Bak Bax.

Specifications and Purity: ≥99%

Molecular Formula: C34H27NO5S2

Molecular Weight: 593.71