VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disordersIn VitroVRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a K d of 190 nM. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 150 nM (VRK1).
Specifications and Purity: ≥99%
Molecular Formula: C18H11F4NO2
Molecular Weight: 349.28
PubChem CID: 155511407
Isomeric SMILES: CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F
- UPC:
- 42281703
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V647791-100mg
- CAS:
- 2378855-09-3
- Product Size:
- 100mg
akash.verma@cenmed.com
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