Vorinostat (SAHA, MK0683) (C007B-305485)

Suberoylanilide Hydroxamic Acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.A potent HDAC inhibitor; also causes cell cycle arrest at G1SAHA may be used to study gene regulation, transcription regulation and cell signaling.

Specifications and Purity: ≥99%

MDL Number: MFCD00945317

Molecular Formula: C14H20N2O3

Molecular Weight: 264.32

PubChem CID: 5311

Isomeric SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

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