UPGL00004 (C007B-304860)

InformationUPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.Targetsglutaminase C (Cell-free assay) 29 nMIn vitroUPGL00004 potently inhibits the growth of triple negative breast cancer cells, as well as tumor growth when combined with the anti-VEGF antibody bevacizumab.In vivoUPGL00004 potently suppresses tumor growth in a patient-derived xenograft model for breast cancer, when combined with the anti-angiogenesis, anti-VEGF monoclonal antibody bevacizumab.Cell Research(from reference)Cell lines：Breast cancer cells Concentrations：0-10 μM Incubation Time：6 days.

Specifications and Purity: ≥98%

Molecular Formula: C25H26N8O2S2

Molecular Weight: 534.66

PubChem CID: 121256411

Isomeric SMILES: C1CN(CCC1NC2=NN=C(S2)NC(=O)CC3=CC=CC=C3)C4=NN=C(S4)NC(=O)CC5=CC=CC=C5