Biochem/physiol Actions
(-)-Umbellulone, isolated from the"headache tree" Umbellularia californica Nutt, is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. (-)-Umbellulone activates TRPA1 channels on nociceptive trigeminal afferents, resulting in release of CGRP and CGRP-mediated neurogenic vasodilatation, causing a painful cold sensation and headache/migraine.
- UPC:
- 42295305
- Condition:
- New
- HazmatClass:
- No
- MPN:
- SML0782-5MG
- CAS:
- 546-78-1
akash.verma@cenmed.com
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