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ucoe intermediate vector set

UCOE(R) INTERMEDIATE VECTOR SET

Catalog No.
C005B-284927
Manufacturer No.
UC0E05
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
KT

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General description The Ubiquitous Chromatin Opening Element (UCOE) technology offers significant advances in recombinant mammalian protein expression. Unlike traditional vectors, UCOE-containing vectors have the capacity to ease the process of

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General description

The Ubiquitous Chromatin Opening Element (UCOE) technology offers significant advances in recombinant mammalian protein expression. Unlike traditional vectors, UCOE-containing vectors have the capacity to ease the process of isolating cell line clones that express high-levels of recombinant proteins. UCOE sequences promote reproducible and stable high level expression of a linked gene by altering chromatin structure to a transcriptionally permissive state that negates epigenetic-mediated (e.g. DNA methylation) silencing.

CET 1019 contains the 3 kb mouse Rps3 UCOE and the 1.5 kb fragment of human HNRPA2B1-CBX3 UCOE.
CET 1310 contains the 8 kb fragment of human HNRPA2B1-CBX3 UCOE.
CET 1316 contains the 4 kb fragment of human HNRPA2B1-CBX3 UCOE.

References
Antoniou, M., et al.. (2003) Transgenes Encompassing Dual Promoter CpG Islands from the Human TBP and HNRPA2B1 Loci are Resistant to Heterochromatin-mediated Silencing. Genomics, 82: 269-279.
Antoniou, M., et al. (2010) A Ubiquitous Chromatin Opening Element (UCOE) Confers Resistance to DNA Methylation-mediated Silencing of Lentiviral Vectors. Mol Ther, 18: 1640-1649.

THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS PRODUCT LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF THE PATENTED UCOE TECHNOLOGY, PLEASE CONTACT licensing@emdmillipore.com.

Components

1) 10ug CET 1019 (3 kb Rps3 and 1.5kb HNRPA2B1-CBX3) Vector (CS221300)

2) 10ug CET 1310 (8 kb HNRPA2B1-CBX3) Vector (CS221301)

3) 10ug CET 1316 (4 kb HNRPA2B1-CBX3) Vector (CS221302)

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

UCOE is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
42202301
Condition:
New
HazmatClass:
No
MPN:
UC0E05
Temperature Control Device:
Yes

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