AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis.
Specifications and Purity: 10mM in DMSO
Molecular Formula: C16H12N2O3
Molecular Weight: 280.28
PubChem CID: 5328771
Isomeric SMILES: C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/T421272-SCI_8300fc622b9a04e7539f19cd7367d394.pdf
- UPC:
- 10161611
- Condition:
- New
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- T421272-1ml
- CAS:
- 133550-35-3
- Health Hazards:
- Toxic
- Product Size:
- 1ml
- Hazard Statement Codes:
- H319:H315:H301
- Precautionary Statement Codes:
- P501:P405:P362+P364:P305+P351+P338:P302+P352:P330:P280:P270:P264
akash.verma@cenmed.com
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