TrkA-IN-4 (C007B-431518)

TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 ( HY-151948 ). TrkA-IN-4 exhibits potent antinociceptive effects.Appearance:SolidIC50& Target:TrkAIn Vitro:TrkA-IN-4 (compound 39) demonstrates 65.1% and 46.3% of kinase inhibition towards TrkA at concentrations of 1 μM and 0.1 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivo:TrkA-IN-4 (compound 39) (0.9375-120mg/kg; i.g.) exhibits stronger maximum antinociceptive effects 3 h after administration, with an ED 50 of 7.836mg/kg in hot plate testing on male mice. MCE has not independently confirmed the accuracy of these metBiological Activity:TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 ( HY-151948 ). TrkA-IN-4 exhibits potent antinociceptive effects.

Specifications and Purity: ≥99%

Molecular Formula: C27H21F3N4O5

Molecular Weight: 538.47