Trimethyl(trifluoromethyl)silane solution (C007B-300282)

General DescriptionTrimethyl(trifluoromethyl)silane (TMSCF 3.Flammable liquid ) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.ApplicationReactant for: Silver-mediated C-H trifluoromethylation of arenes Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8 Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts Palladium-catalyzed oxidative trifluoromethylation of indoles Preparation of 5-HT1A antagonists Used as difluorocarbene source TMSCF 3.Flammable liquid can be used as a reagent for: Conversion of aromatic aldehydes to difluoromethylated products. C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction. It can also be used in trifluoromethylation of: Non-activated aldimines. Heterocumulenes. Azomethine imines.

Specifications and Purity: 2 M in THF

Molecular Formula: C4H9F3Si

Molecular Weight: 142.19

PubChem CID: 552549

Isomeric SMILES: C[Si](C)(C)C(F)(F)F

Beilstein Registry Number: 4241868

Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T434250-SCI_75a8cb1e60237f5c59fbdaeefeddaaec.pdf