TP-238 hydrochloride

TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC 50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC 50 of 5.9 and is less active against other 338 kinasesIn VitroTP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:CECR2|30 nM (IC|50|)|CECR2|10 nM (Kd)|CECR2|7.5 (pIC|50|)|BPTF|350 nM (IC|50|)|BPTF|120 nM (Kd)|BPTF|6.5 (pIC|50|)|BRD9|5.9 (pIC|50|).

Specifications and Purity: ≥98%

Molecular Formula: C22H31ClN6O3S

Molecular Weight: 495.04

PubChem CID: 146018950