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toyocamycin

TOYOCAMYCIN FROM STREPTOMYCES RIMOSUS

Catalog No.
C005B-287693
Manufacturer No.
T3580-10MG
Manufacturer Name
Sigma-Aldrich
Quantity
10
Unit of Measure
MG

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Biochem/physiol Actions Studies have implicated that toyocamycin blocks the replication of fowl plague virus. Toyocamycin is a nucleoside- type antibiotic analogue of adenosine, isolated from Streptomyces species.

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Biochem/physiol Actions

Studies have implicated that toyocamycin blocks the replication of fowl plague virus.

Toyocamycin is a nucleoside- type antibiotic analogue of adenosine, isolated from Streptomyces species. Toyocamycin is an anti-tumor antibiotic with various target activities. Toyocamycin is a potent inhibitor of RNA self-cleavage in mammalian cells. It also inhibits phosphatidylinositol kinase, a cell proliferation regulator. Toyocamycin was also found to inhibit Auxin signaling. Auxins are plant hormones with a crucial role in plant development regulation, and Toyocamycin was found to specifically inhibit auxin-responsive gene expression.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Toyocamycin is soluble in DMSO at 0.90 - 1.10 mg/ml and yields a clear, colorless solution. It is also soluble in acidic solutions and is moderately soluble in water, methanol and ethanol. Solutions prepared in DMSO can be diluted 10-fold in water.

UPC:
51111704
Condition:
New
HazmatClass:
No
MPN:
T3580-10MG
CAS:
606-58-6

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