TEMPOL 1PC X 500MG

General description

A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21^WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21^WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Free radical scavenger and nitric oxide spin trap

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.
Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.
Mota-Filipe, H., et al. 1999. Shock 12, 255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 172.24. Empirical Formula: C₉H₁₈NO₂. Quality Level: 100. Assay: ≥. 97% total nitrogen (N) basis. form: crystals, powder. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: orange. solubility: DMSO: 5 . mg/mL, ethanol: soluble, water: soluble. shipped in: ambient. storage temp.: −. 20°C. InChI: 1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3. InChI key: UZFMOKQJFYMBGY-UHFFFAOYSA-N. Pictograms: GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H302 - H318 - H373. Precautionary Statements: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314. Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2 Oral. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): 294.8 °F - DIN 51758. Flash Point(C): 146 °C - DIN 51758.