TBUXPHOS PD G3 CHEMBEADS

General description

tBuXPhos Pd G3 is a third generation (G3) Buchwald precatalyst. It is air, moisture and thermally-stable and is highly soluble in a wide range of common organic solvents. It has long life in solutions. tBuXPhos Pd G3 is an excellent reagent for Buchwald-Hartwig cross-coupling reaction. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

For larger scale uses, product also available in powdered form (762229)

Application

tBuXPhos Pd G3 may be used to synthesize 4-cyano-7-azaindole from 4-chloro-7-azaindole by cyanation reaction. It may also be used for the α-arylation reaction of acetate esters at room temperature.

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

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Other Notes

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

Molecular Weight: 794.37. Empirical Formula: C₄₂H₅₈NO₃PPdS. Assay: ~6 wt.% loading of catalyst. Quality Level: 100. form: solid. reaction suitability: reagent type: catalyst
reaction type: Cross Couplings. extent of labeling: ~6 . wt. % loading of catalyst. SMILES string: O: S([O-][Pd+2]1(P(C(C)(C)C)(C(C)(C)C)C2: CC: CC: C2C3: C(C(C)C)C: C(C(C)C)C: C3C(C)C)[C-]4: C(C5: C(N1)C: CC: C5)C: CC: C4)(C): O. InChI: 1S/C29H45P.C12H10N.CH4O3S.Pd/c1-19(2)22-17-24(20(3)4)27(25(18-22)21(5)6)23-15-13-14-16-26(23)30(28(7,8)9)29(10,11)12. 13-12-9-5-4-8-11(12)10-6-2-1-3-7-10. 1-5(2,3)4. /h13-21H,1-12H3. 1-6,8-9H,13H2. 1H3,(H,2,3,4). /q. . . +1/p-1. InChI key: SQQOHCLJPLSJGX-UHFFFAOYSA-M. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.