TBUBRETTPHOS 97% (C005B-009923)

General description

tBuBrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.

tBuBrettPhos is a phosphine ligand widely used in palladium-catalyzed cross-coupling reactions.

Application

Buchwald Phosphine Ligands for chemical Synthesis

Common applications

• Buchwald-Hartwig amination and C-O coupling
• Suzuki, Negishi, Stille, Hiyama, Sonogashira cross-couplings
• α-Arylation reaction

New Applications:

• Conversion of aryl and vinyl triflates to bromides and chlorides
• Conversion of aryl triflates to aryl fluorides
• O-Arylation of ethyl acetohydroximate
• Conversion of aryl chlorides and sulfonates to nitroaromatics

Features and Benefits

• White crystalline solid
• Air- and moisture-stable
• Thermally stable
• Highly efficient
• Wide functional group tolerance
• Excellent selectivity and conversion

Legal Information

Usage subject to US Patent 7,858,784

Molecular Weight: 484.69. Empirical Formula: C₃₁H₄₉O₂P. Quality Level: 300. Assay: 97%. form: solid. reaction suitability: reaction type: Cross Couplings, reagent type: ligand
reaction type: Arylations, reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: ligand
reaction type: C-X Bond Formation, reagent type: ligand
reaction type: Fluorinations. mp: 166-170 . °C. functional group: phosphine. SMILES string: COc1ccc(OC)c(c1P(C(C)(C)C)C(C)(C)C)-c2c(cc(cc2C(C)C)C(C)C)C(C)C. InChI: 1S/C31H49O2P/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12/h15-21H,1-14H3. InChI key: REWLCYPYZCHYSS-UHFFFAOYSA-N. Storage Class Code: 13 - Non Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.