Syk Inhibitor II (C007B-270471)

Catalog No.: C007B-270471
Manufacturer No.: S341312-1mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

Syk Inhibitor II, a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM), while affecting PKCe, PKCbII, ZAP-70, Btk, and Itk only at much higher concentrations (IC50 = 5.1, 11, 11.2, 15.5, and 22.6μM, respectively). Inhibits FceRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and passive cutaneous anaphylaxis (PCA) reaction in mice in vivo (ID50 = 13.2 mg/kg, s.c.).

Molecular Formula: C14H15F3N6O•2HCl•2H2O

Molecular Weight: 449.26

PubChem CID: 16760670

Isomeric SMILES: C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)NCCN)C(F)(F)F.O.O.Cl.Cl

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/S341312-SCI_22fb381017f09dcb4d16729689a161af.pdf

UPC:: 51142509
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: S341312-1mg
CAS:: 227449-73-2
Product Size:: 1mg
Precautionary Statement Codes:: P264

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