An oxindole compound that potently blocks Syk activity (IC50 = 5 nM) and inhibits Fc&epsilonRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 &muM) 2 &muM completely abolishes convulxin-induced platelet
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An oxindole compound that potently blocks Syk activity (IC50 = 5 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 μM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change.
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