Subasumstat (TAK-981) (C007B-272730)

InformationSubasumstat (TAK-981) Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.TargetsSUMOylation enzymatic cascadeIn vitroIn both mouse bone-marrow and human peripheral blood mononuclear cell derived dendritic cells (DCs), TAK-981 treatment ex vivo induced markers of activation and maturation including CD40, CD80 and CD86, as well as increased secretion of inflammatory cytokines like IP-10, MCP1, MIP-1α, MIP1β, IFNα and IFNβ.In vivoa single sub-cutaneous injection of TAK-981 in naïve Balb/c mice at the brachial lymph nodes induced activation of DCs, measured as significant increases in CD40 and CD86 expression. TAK-981 demonstrates antitumor activity, including complete regression (CR) of some tumors, in immune-competent BALB/c mice bearing syngeneic A20 lymphoma tumors.Cell Research(from reference)Cell lines：mouse bone-marrow and human peripheral blood mononuclear cell derived dendritic cells (DCs).

Specifications and Purity: ≥98%

Molecular Formula: C25H28ClN5O5S2

Molecular Weight: 578.10

PubChem CID: 118628567

Isomeric SMILES: CC1=C(C=C(S1)C(=O)C2=CN=CN=C2N[C@@H]3C[C@@H]([C@H](C3)O)COS(=O)(=O)N)[C@H]4C5=C(CCN4)C=CC(=C5)Cl