STING agonist-16 (C007B-418804)

STING agonist-16 (1a) is a specific stimulator of interferon genes ( STING ) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool.In VitroSTING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1). STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells. STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC 50 value of 16.77 μM while 2'3'-cGAMP acts with an EC 50 value of 9.212 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid.

Molecular Formula: C19H11Cl2N5O

Molecular Weight: 396.23

PubChem CID: 1002560

Isomeric SMILES: COC1=CC2=CC(=C(N=C2C=C1)Cl)C3=NN=C4N3C5=CC=CC=C5N=C4Cl