Stat5 Inhibitor (C007B-270442)

Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses STAT5 via binding to the SH2 domain. Studies indicate that Stat5 Inhibitor suppresses the SH2 domain of STAT1 and STAT3 to a lesser extent than STAT5 inhibition. In addition, STAT5/STAT5 DNA binding in K562 nuclear extracts are inhibited by Stat5 Inhibitor. STAT5 functions biologically in various processes such as homeostasis of hematopoietic stem cells, development of blood cells, growth hormone effects, and differentiation of mammary epithelium. Stat5 Inhibitor is shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.

Specifications and Purity: ≥98%

Molecular Formula: C16H11N3O3

Molecular Weight: 293.28

PubChem CID: 9566174

Isomeric SMILES: C1=CC=C2C(=C1)C(=O)C(=CO2)/C=N/NC(=O)C3=CN=CC=C3

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