SRT2104 (GSK2245840) (C007B-272984)

InformationSRT2104 (GSK2245840) is a selectiveSIRT1activator involved in the regulation of energy homeostasis. Phase 2.TargetsSIRT1In vitroSRT2104 reduces p65/RelA acetylation levels in C2C12 cells.In vivoIn male C57BL/6J mice, SRT2104 (100 mg/kg, p.o.) extends both mean and maximal lifespan of mice fed a standard diet, and enhances motor coordination, bone mineral density, and insulin sensitivity and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.Cell Research(from reference)Cell lines：C2C12 cell line Concentrations：3/xa0μM Incubation Time：24 h.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C26H24N6O2S2

Molecular Weight: 516.64

PubChem CID: 25108829

Isomeric SMILES: CC1=C(SC(=N1)C2=CN=CC=C2)C(=O)NC3=CC=CC=C3C4=CN5C(=CSC5=N4)CN6CCOCC6