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sri-42127 (c09-1170-258)

SRI-42127 (C007B-418426)

Catalog No.
C007B-418426
Manufacturer No.
S649484-25mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter

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SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytesIn VitroSRI-42127 (0.05-1 μM; 24 h) blocks HuR cytoplasmic translocation stimulated by LPS (1 μg/mL) in primary microglia. SRI-42127 (0.05-1 μM; 24 h) suppresses inflammatory cytokine and chemokine mRNA in activated Primary microglia cells (PMG). SRI-42127 (0.5 μM and 1 μM; 24 h) blocks glial-produced chemoattraction/migration signals for neutrophils and monocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoSRI-42127 (15 mg/kg; i.p.; single dose) suppresses HuR translocation and the activation of microglia in mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:HuR.

Specifications and Purity: ≥99%

Molecular Formula: C19H20N6O

Molecular Weight: 348.40

UPC:
12131508
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
S649484-25mg
CAS:
2727872-68-4
Product Size:
25mg

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