SPP86 (C005B-312111)

Catalog No.: C005B-312111
Manufacturer No.: SML1435-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC 50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or

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Description
Specifications

Biochem/physiol Actions

SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC₅₀ value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC₅₀ value of 1.0 μM, similar to tamoxifen.

UPC:: 41113401
Condition:: New
HazmatClass:: No
MPN:: SML1435-5MG
CAS:: 1357349-91-7

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