SP-96 (C007B-272812)

InformationSP-96 is a potent, selective and non-ATP-competitive inhibitor ofAurora Bwith IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).TargetsAurora B (Cell-free assay) 0.316 nMIn vitroSP-96 shows sub-nanomolar potency in Aurora B enzymatic assays (IC50 = 0.316 ± 0.031 nM). SP-96 shows >2000 fold selectivity against FLT3 and KIT which is important for normal hematopoiesis. Enzyme kinetics of SP-96 shows non-ATP competitive inhibition which makes it a first-in-class inhibitor. SP-96 shows selective growth inhibition in NCI60 screening, including inhibition of MDA-MD-468, a Triple Negative Breast Cancer cell line.Cell Research(from reference)Cell lines：MCF-7 cells Incubation Time：24 h.

Specifications and Purity: ≥99%

Molecular Formula: C25H20FN7O

Molecular Weight: 453.47

PubChem CID: 154573766

Isomeric SMILES: CN1C=C(C=N1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC(=CC=C4)NC(=O)NC5=CC(=CC=C5)F

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