SKF 83822 (C007B-418236)

SKF 83822 is an atypical agonist of dopamine D1 receptor . SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophreniaIn VivoSKF 83822 (25-100 μg/kg; s.c.; single dose after antagonist) produces a strong rotational response in rat in a dose-dependent manner. And it also stimulates strong expression of the IEG products c-Fos, Fra2, Zif/268 and Arc in the deinnervated striatum . SKF 83822 shows significant effects in a moderate and high dose with 0.25 mg/kg and 0.35 mg/kg, respectively, in monkeys. And it (0.15-0.35 mg/kg; s.c.; single dose) induces locomotion but nor inducing dyskinesia. SKF 83822 results in a state of extreme arousal and locomotor activation without stereotypy. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult, male Sprague-Dawley derived rats Dosage: 6.25 μg/kg, 25 μg/kg, 50 μg/kg, and 100 μg/kg; with or without 0.5 mg/kg antagonist SCH 23390. Administration: SC; single dose, 30 min after antagonist treatment. Result: Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment. Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.Form:SolidIC50& Target:Rat D 1 Receptor.

Specifications and Purity: ≥98%

Molecular Formula: C20H22ClNO2

Molecular Weight: 343.85

EC Number: 804-119-6

PubChem CID: 10020353

Isomeric SMILES: CC1=CC(=CC=C1)C2CN(CCC3=C(C(=C(C=C23)O)O)Cl)CC=C