SJB2-043 (C005B-308626)

Catalog No.: C005B-308626
Manufacturer No.: SML3659-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: EA

Biochem/physiol Actions SJB2-043 is a ubiquitin-specific protease USP1 inhibitor (IC50 = 544 nM using USP1/UAF1 complex) that exhibits anti-proliferation efficacy against chronic and acute myeloid leukemia lines (IC50 <:2 µ:M: K562,

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Description
Specifications

Biochem/physiol Actions

SJB2-043 is a ubiquitin-specific protease USP1 inhibitor (IC50 = 544 nM using USP1/UAF1 complex) that exhibits anti-proliferation efficacy against chronic and acute myeloid leukemia lines (IC50 <2 µM; K562, OCI-AML3, SK-NO1, U937) and primary acute myelogenous leukemia (AML) patient-derived leukemic cells by promoting the degradation of transcription factor DNA binding 1 (ID1). SJB2-043 is also reported to be an allosteric site-targeting inhibitor against PLPro (IC50 = 0.56 μM), the papain-like cysteine protease with deubiquitination and deISGylation activities that suppress host innate immune responses toward SARS-CoV-2 infection.

UPC:: 12141616
Condition:: New
HazmatClass:: No
MPN:: SML3659-25MG
CAS:: 63388-44-3

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