Biochem/physiol Actions SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC 50 = 77 nM by cell-free assays: IC 50 = 0.8 μ:M against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells)
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SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 77 nM by cell-free assays; IC50 = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.
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