SDZ 220-581 hydrochloride (C007B-419084)

SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pK i value of 7.7In VivoSDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male OF-l mice (18-26 g) Dosage: 3.2 mg/kg, 10 mg/kg, 32 mg/kg Administration: Oral administration; for 24 hours Result: Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.IC50& Target:pKi: 7.7 ( NMDA receptor ).

Specifications and Purity: 10mM in DMSO

Molecular Formula: C16H18Cl2NO5P

Molecular Weight: 406.2