SCH 28080 (C005B-366934)

Catalog No.: C005B-366934
Manufacturer No.: S4443-50MG
Manufacturer Name: Sigma-Aldrich
Quantity: 50
Unit of Measure: MG

Application SCH-28080 was used to treat zebrafish embryos to study the role of H + /K + -ATPase in establishment of left-right axis during development. Biochem/physiol Actions SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase.

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Description
Specifications

Application

SCH-28080 was used to treat zebrafish embryos to study the role of H⁺/K⁺-ATPase in establishment of left-right axis during development.

Biochem/physiol Actions

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC₅₀s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC₅₀ of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

UPC:: 85111505
Condition:: New
HazmatClass:: No
MPN:: S4443-50MG
CAS:: 76081-98-6

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