SC-514 (C005B-313231)

Catalog No.: C005B-313231
Manufacturer No.: SML0557-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Application SC-514 has been used to study its effect on lipopolysaccharide (LPS)-induced phosphorylation of NF-κ:B (nuclear factor-κ:B) p65 and p38 MAPK (mitogen-activated protein kinase). Biochem/physiol Actions SC-514 is a

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Description
Specifications

Application

SC-514 has been used to study its effect on lipopolysaccharide (LPS)-induced phosphorylation of NF-κB (nuclear factor-κB) p65 and p38 MAPK (mitogen-activated protein kinase).

Biochem/physiol Actions

SC-514 is a cell-permeable, potent and selective ATP competitive inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) that specifically blocks NF-?B-dependent gene expression. SC-514 exhibits anti-inflammatory properties.

SC-514 is an amino-acetamide compound. It is selective for IKKβ with an IC50 value of 3−12 μM. SC-514 also inhibits cytokines such as interleukin-6 (IL-6) and IL-8, mediated by IKKβ. IKKβ is responsible for osteoclast survival, hence its inhibition affects osteogenesis.

UPC:: 41102702
Condition:: New
HazmatClass:: No
MPN:: SML0557-5MG
CAS:: 354812-17-2

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