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sc-26196 (c15-1848-584)

SC-26196 (C005B-432699)

Catalog No.
C005B-432699
Manufacturer No.
PZ0176-5MG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
MG

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Application SC-26196 has been used as an inhibitor of delta6 (Δ:6) fatty acid desaturase: in mouse inner medullary :collecting duct :(IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′:s modified

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Application

SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase:

  • in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component
  • in hepatic HepG2 cells
  • in glioblastoma cell lines to test its effect post-radiation treatments

Biochem/physiol Actions

SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.

Other Notes

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

UPC:
12141613
Condition:
New
HazmatClass:
No
MPN:
PZ0176-5MG

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