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sb 239063 (c15-1792-912)

SB 239063 (C005B-377822)

Catalog No.
C005B-377822
Manufacturer No.
S0569-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG

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General description SB 239063 helps to decrease neutrophilia, inflammatory cytokines, matrix metallopeptidase 9 (MMP-9) and fibrosis in the lung. Application SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38

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General description

SB 239063 helps to decrease neutrophilia, inflammatory cytokines, matrix metallopeptidase 9 (MMP-9) and fibrosis in the lung.

Application

SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38 MAP kinase, and extracellular signal regulated protein kinase (ERK)/p42/p44 mitogen activated protein kinase (MAPK) on the viability and apoptosis of cardiomyocytes under glutathione S-transferase (GST) inhibition. It has also been used in neuron-microglia conditioned media (CM) experiments and pharmacokinetics.

Biochem/physiol Actions

Potent p38 MAP kinase inhibitor. Selective for α and β. No activity against γ and δ isoforms.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

UPC:
10161807
Condition:
New
HazmatClass:
No
MPN:
S0569-25MG
CAS:
193551-21-2

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