SANGUINARINE CHLORIDE HYDRATE (C005B-362010)

Application

Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.⁹ It was tested for anti-lipase activity against Candida rugosa lipase.¹⁰

Sanguinarine chloride hydrate yields clear, orange solution in methanol at 20 mg/ml.

Biochem/physiol Actions

A natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Has antiproliferative, pro-apoptosis effects in some cancer cell lines.

Sanguinarine is a benzophenanthridine alkaloid isolated from plants belonging to the family Papaveracea. It exhibits anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties. It induces cell cycle arrest and sensitizes cancer cells to apoptosis by activating TNF-related apoptosis inducing ligand.^6,7 It inhibits STAT3, MMP-2, MMP-9, interacts with glutathione, induces generation of ROS, disrupts the microtubule assembly and causes DNA damage resulting the death of the cancer cells.^6,7,8