Sanggenon G (C007B-418075)

Catalog No.: C007B-418075
Manufacturer No.: S647929-1mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activationIn VitroSanggenon G (14.4 μM, 24 h) enhances caspase-8, -3 and -9 cleavage, displaces caspase-9 from XIAP and sensitizes Molt3/XIAP cells to Etoposide (HY-13629)-induced apoptosis. Sanggenon G not only sensitizes the XIAP-overexpressing leukemia cell line Molt3/XIAP to Etoposide (HY-13629) treatment but also different neuroblastoma cell lines endogenously expressing high XIAP levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Caspase-3 Caspase-8 Caspase-9.

Molecular Formula: C40H38O11

Molecular Weight: 694.72

UPC:: 12141739
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: S647929-1mg
CAS:: 85698-31-3
Product Size:: 1mg

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