(S)-V-0219 hydrochloride (C007B-419295)

(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-Appearance:SolidIC50& Target:GLP-1RIn Vitro:(S)-V-0219 ((S)-9) (0.1 nM) hydrochloride potentiates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 (0.1 nM) hydrochloride potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 underIn Vivo:(S)-V-0219 ((S)-9) (0.04-0.2mg/kg; i.p.) hydrochloride improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats. (S)-V-0219 (0. 4mg/kg; i.g.) hydrochloride is orally active in fatty diabetic Zucker rats. (S)-V-021Biological Activity:(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-.

Specifications and Purity: ≥99%

Molecular Formula: C20H26ClF3N4O2

Molecular Weight: 446.89