(S)-SIPHOS-PE 97%

Application

(S)-SIPHOS-PE is a chiral spiro phosphoramidate ligand that can be used to synthesize:

• Spiroindolenines by Pd-catalyzed intramolecular dearomative arylation of haloaryl-3-substituted indoles.
• Enantioselective conjugate addition compound by Cu-catalyzed 1,4-addition of diethylzinc (Et₂Zn) to cyclic enones.
• Octaketide natural products via rhodium-phosphoramidite catalyzed alkene hydroacylation.

Molecular Weight: 505.59. Empirical Formula: C₃₃H₃₂NO₂P. Quality Level: 100. Assay: 97%. form: powder. optical activity: [α. ]22/D −. 65.0°, c :  . 1 in chloroform. mp: 120-125 . °C. storage temp.: −. 20°C. SMILES string: C[C@@H](N([C@H](C)c1ccccc1)P2Oc3cccc4CCC5(CCc6cccc(O2)c56)c34)c7ccccc7. InChI: 1S/C33H32NO2P/c1-23(25-11-5-3-6-12-25)34(24(2)26-13-7-4-8-14-26)37-35-29-17-9-15-27-19-21-33(31(27)29)22-20-28-16-10-18-30(36-37)32(28)33/h3-18,23-24H,19-22H2,1-2H3/t23-,24-,33?/m1/s1. InChI key: ZXLQLIDJAURBDD-HRPAVAKOSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H315 - H319 - H335. Precautionary Statements: P261 - P305 + P351 + P338. Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.