RO 4938581 (C007B-415556)

RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a , and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a ( K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.In VitroRO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K i , 174, 185, 80 nM, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoRO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Ki: 4.6 nM (GABA A α5β3γ2a), 174 nM (GABA A α1β3γ2a), 185 nM (GABA A α2β3γ2a), 80 nM (GABA A α3β3γ2a).

Specifications and Purity: ≥99%

Molecular Formula: C13H8BrF2N5

Molecular Weight: 352.14

PubChem CID: 11624499

Isomeric SMILES: C1C2=C(N=CN2C3=C(C=C(C=C3)Br)C4=NC=NN41)C(F)F